The TEM enables high-magnification and high-resolution imaging of (practically) any biological sample - histological samples, cell cultures, organelles, microorganisms, viruses - as well as the visualization of macromolecules and polymers.
- Reinforcement and support to clinical diagnosis of several pathologies:
- Renal: diagnosis of primary and secondary glomerulopathies
- Muscular: support in the diagnosis of congenital, mitochondrial, nemaline and metabolic myopathies by inclusion bodies (amyloid, Tay-Sachs, etc.)
- Metabolic: study of hereditary pathologies such as mucopolysaccharidosis, neuronal ceroid lipofuscinosis, Anderson-Fabry disease by accumulation of myeloid bodies, etc.
- Dermatological: differentiation of congenital epidermolysis bullosa types
- Pathology of the peripheral nervous system: support in the diagnosis of Guillain–Barré syndrome (acute inflammatory demyelinating polyneuropathy) by alterations in the myelin
- Hypophyseal: reinforcement in the diagnosis of pituitary adenomas
- Identification of intranuclear and cytoplasmic viral particles
- Observation of the structure and morphology of viruses, bacteria, exosomes, microvesicles, proteins and certain chemical compounds.
- Study of morphological effects (increase of vacuoles, autophagosomes, lipid droplets, etc.) of drugs in cell culture lines.
- Monitoring of the proliferation, differentiation and integration of previously tagged (e.g. with GFP, RFP,...) stem cells that have been transplanted in target tissue.
- Functional studies of some proteins: observation of morphological changes in experimental animals due to the absence or overexpression of a given protein.
- Localization of protein expression at the cellular level (membrane, cytoplasm, nucleus, extracellular matrix, etc) by immunohistochemistry (with colloidal gold or DAB).